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Reference type: Journal
Authors: Venkatesh S, Sizemore SP, Byrne ME
Article Title: Biomimetic hydrogels for enhanced loading and extended release of ocular therapeutics.
Publication date: 2007
Journal: Biomaterials
Volume: 28
Issue: (4)
Page numbers: 717-724.
DOI: 10.1016/j.biomaterials.2006.09.007
Alternative URL: http://www.sciencedirect.com/science/article/B6TWB-4M04J73-1/2/4f281cfa1408a5b8841b4ace81fca2d3

Abstract: We have applied the principles of biomimesis by incorporating a natural receptor-based rational design strategy in the synthesis of novel recognitive soft contact lenses. We have demonstrated the potential of biomimetic carriers to load significant amounts of ocular medication such as H1-antihistamines, as well as to release a therapeutic dosage of drug in vitro in a controlled fashion for 5 days, with an even further extension in the presence of protein. Gels of multiple complexation points with varying functionalities outperformed gels formed with less diverse functional monomers and showed superior loading with a six-fold difference over control gels and a three-fold difference over less biomimetic gels. Moreover, mechanical and optical properties of these hydrogels agreed with conventional lenses, and increased loading was reflected in a reduced propagation of polymer chains. This approach can be extended to a wider biological spectrum in the design of novel, controlled and modulated delivery devices to alleviate ocular disorders and provide an alternative to topical therapy
Template and target information: ketotifen
Author keywords: Biomimetic hydrogel, Ophthalmic drug delivery, Extended release, molecular imprinting, Differential scanning calorimetry (DSC), Therapeutic contact tenses

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