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Reference type: Journal
Authors: Hall AJ, Quaglia M, Manesiotis P, DeLorenzi E, Sellergren B
Article Title: Polymeric Receptors for the Recognition of Folic Acid and Related Compounds via Substructure Imprinting.
Publication date: 2006
Journal: Analytical Chemistry
Volume: 78
Issue: (24)
Page numbers: 8362-8367.
DOI: 10.1021/ac0615652

Abstract: A range of 2-acrylamidopyridines, showing subtle differences in solution binding toward carboxylic acids, has been investigated as functional monomers in molecular imprinting. Imprinting of N-Z-L-glutamic acid with one such monomer is shown to be effective in the creation of a molecularly imprinted polymer (MIP) with recognition properties for its template and also for larger molecules containing glutamic acid residues. In comparison to a MIP prepared via a more "traditional" approach, the new polymeric receptors exhibit reduced nonspecific binding. The new receptors are compared with previously reported urea-based receptors targeting the glutamic acid residue and receptors targeting the pteridine substructure of folic acid.
Template and target information: N-Z-L-glutamic acid, folic acid

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