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Reference type: Journal
Authors: Xiong Y, Zhou HJ, Zhang ZJ, He DY, He C
Article Title: Flow-injection chemiluminescence sensor for determination of isoniazid in urine sample based on molecularly imprinted polymer.
Publication date: 2007
Journal: Spectrochimica Acta Part A-Molecular and Biomolecular Spctroscopy
Volume: 66
Issue: (2)
Page numbers: 341-346.
DOI: 10.1016/j.saa.2006.03.001
Alternative URL: http://www.sciencedirect.com/science/article/B6VNG-4JDTKVV-5/2/4209b0a189deef626a2ed5e2950ac60e

Abstract: In this paper, molecularly imprinted polymer (MIP) of isoniazid is synthesized through thermal radical copolymerization of metharylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) in the presence of isoniazid template molecules. A novel flow injection chemiluminescence sensor for isoniazid determination is developed by packing the isoniazid-MIP into the flow cell as recognition elements. Isoniazid could be selectively adsorbed by the MIPs and the adsorbed isoniazid was sensed by its great enhancing effect on the weak CL reaction between luminol and periodate which were mixed in the flow cell. The enhanced CL intensity is linear in the range 2 x 10-9 to 2 x 10-7 g/mL and the detection limit is 7 x 10-10 g/mL (3σ) isoniazid with a relative standard deviation 2.8% (n = 9) for 8 x 10-8 g/mL. The sensor is reversible and reusable. It has a great improvement in sensitivity and selectivity for CL analysis. As a result, the sensor has been successfully applied to determination of isoniazid in human urine. At the same time, the binding characteristic of the polymer to isoniazid was evaluated by batch method and the dynamic method, respectively
Template and target information: isoniazid
Author keywords: Isoniazid, molecularly imprinted polymer, Chemiluminescence sensor


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