Authors: Li ZY
, Liu ZS
, Zhang QW
, Duan HQ
Chiral separation by (S)-naproxen imprinted monolithic column with mixed functional monomers.
Publication date: 2007
Journal: Chinese Chemical Letters
Alternative URL: http://www.sciencedirect.com/science/article/B8G3X-4N1SK27-P/2/3c26ce43d167e17d7fb01d5b664279c5
Abstract: Molecularly imprinted polymers (MIPs), using (S)-naproxen as template and the combination of butyl methacrylate (BMA) and MAA (1:1 molar ratio) as functional monomers were synthesized by an in situ polymerization reaction. The rendered monolithic column was evaluated in HPLC mode. The result showed that the monolithic MIPs with the combination of two monomers produced better chiral resolution of rac-naproxen (Rs = 1.55) and column efficiencies of imprinted molecules (N = 2860 plates/m) than that with pure MAA
Template and target information: naproxen, (S)-naproxen
Author keywords: molecularly imprinted polymer, monolithic column, naproxen, chiral separation
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