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Reference type: Journal
Authors: Villar P, Whitcombe MJ, Vulfson EN
Article Title: Matrix effects on the selectivity of a cholesterol-imprinted polymer.
Publication date: 2007
Journal: Polymer
Volume: 48
Issue: (6)
Page numbers: 1483-1489.
DOI: 10.1016/j.polymer.2007.01.043
Alternative URL: http://www.sciencedirect.com/science/article/B6TXW-4MWXPX6-6/2/17be45e11c649eb93f78c8bfca35baea

Abstract: The effect of cross-linkers ethyleneglycol dimethacrylate (EGDM) and divinylbenzene (DVB) on the recognition properties of cholesterol-imprinted polymers, prepared by the sacrificial spacer method, was investigated. As reported previously EGDM-based polymers selectively bound cholesterol in preference to cholest-5-ene-3-one. The addition of up to 30% DVB led to an increase in the binding capacity with very little trade-off in selectivity. However polymers prepared with pure DVB, or DVB/styrene showed complete reversal of selectivity, in some cases binding cholest-5-ene-3-one to the exclusion of cholesterol from a solution containing both ligands. An explanation based on template conformation has been proposed to account for these observations
Template and target information: cholesterol, cholest-5-ene-3-one
Author keywords: cholesterol, molecular imprinting, selectivity


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