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Abstract: The interaction of 17β-estradiol (17β-E) and its structural analogues with six different functional monomers, namely methyl methacrylate (MMA), acrylamide (AM), methacrylamide (MA), 4-vinylpyridine (4-VP), methacrylic acid (MAA) and 2-(trifluoromethyl) acrylic acid (TFMAA) has been studied by ultraviolet (UV) spectroscopy, infrared (IR) spectroscopy and high pressure liquid chromatography (HPLC), and molecularly imprinted polymers (MIP)subsequently synthesized by precipitation polymerization. The O - H and C = 0 IR absorption maxima shift towards higher wavenumbers after imprinting 17β-E on a TFMAA-co-TRIM copolymer (TRIM = trimethylolpropane trimethacrylate) with the red shift of the O- H groups being apparent after precipitation polymerization for 16 h, and that for the C = 0 groups being observed after polymerization for 24 h. The strong interaction between TFMAA and 17β-E was confirmed by the high selectivity for 17β-E, as indicated by the values of the separation factor (α) of isomers of 17β-E/17α-E (2.28) and the imprinted factor (IF) (3.01). The results show that in order to select a suitable functional monomer for fabrication of polymers selective to 17β-E and its structural analogues, preliminary screening may be carried out by monitoring the interaction between monomer and template by UV analysis; subsequently, the MIP should be synthesized, and IR and HPLC employed in order to characterize the properties of the polymer
Template and target information: 17β-estradiol, 17β-E, E2
Author keywords: 17β-estradiol, food safety, molecular recognition, Molecularly imprinted polymers, Spectral analysis