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Reference type: Conference Proceeding
Authors: Moreno-Bondi MC, Urraca JL, Benito-Peña E, Navarro-Villoslada F, Martins FA, Orellana G, Sellergren B
Publication date: 2007
Article title: Molecularly imprinted polymers as biomimetic receptors for fluorescence-based optical sensors.
Page numbers: Art. No. 66190C
DOI: 10.1117/12.738347

Editors: Cutolo A, Culshaw B, López-Higuera JM
Conference information: Proceedings of the Third European Workshop on Optical Fibre Sensors

Abstract: Molecularly imprinted polymers (MIPs), human-made polymers capable of recognizing a particular molecule in the presence of others due to the selective cavities of the material, have been successfully applied to the development of chromatographic and solid phase extraction methods. They have also been applied to the development of electrochemical, piezoelectrical and optical sensors. In parallel with the classification of biosensors, MIP-based devices can work according to two different detection schemes: (1) affinity sensors ("plastic-bodies") and, (2) catalytic sensors ("plastic-enzymes"). In the first case the change in a characteristic optical property, most frequently fluorescence, of the analyte or of the polymer is monitored, upon their mutual interaction. Alternatively, a fluorescent analogue of the target analyte can also be used to develop sensors based on competitive assays (MIAs). Optimization of the polymer composition and, in particular, a proper choice of the nature of the functional monomers involved in the polymerization process, is critical to prepare materials able to selectively interact with the analyte in aqueous media and with the fast kinetics required for analytical applications. Moreover, a rational design of fluorescent analogues of non-naturally fluorescent templates or of fluorescent monomers able to change its property upon interaction with the analyte, is also a bottle neck for wide application of this recognition elements in optical sensing. In this paper we present several approaches to address these issues namely the optimization of MIP composition and the design and synthesis of novel fluorophores for the analysis of antibiotics and mycotoxins in real samples.
Template and target information: Review - MIPs
Author keywords: Molecularly imprinted polymers, fluorescence, Optical sensor, antibiotics, penicillin, fluoroquinolone, mycotoxin, zearalenone

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