MIPs logo MIPdatabase      MIP2024 Conference banner, website is now open, register on site for important updates   
Custom Search
Reference type: Journal
Authors: O'Mahony J, Karlsson BCG, Mizaikoff B, Nicholls IA
Article Title: Correlated theoretical, spectroscopic and X-ray crystallographic studies of a non-covalent molecularly imprinted polymerisation system.
Publication date: 2007
Journal: Analyst
Volume: 132
Issue: (11)
Page numbers: 1161-1168.
DOI: 10.1039/b706258c
Alternative URL: https://www.researchgate.net/publication/5890916_Correlated_theoretical_spectroscopic_and_X-ray_crystallographic_studies_of_a_non-covalent_molecularly_imprinted_polymerisation_system

Abstract: The correlation of the recognition properties of a molecularly imprinted polymer (MIP) with the recognition events in pre-polymerisation mixtures is of central importance to our understanding of the molecular imprinting technique. Using the NSAID naproxen as a model template, we have applied parallel theoretical (molecular dynamics) and practical (1H-NMR, X-ray crystallography, HPLC, radioligand binding) methods to examine the nature of template-functional monomer complexation. An effective imprint is achieved, despite the presence of only one site on the template which provides for the formation of effective electrostatic interactions with the functional monomer used, 4-vinylpyridine. This is attributed to the creation of a well-defined receptor site for the acidic terminus of the molecule and complementary van der Waals interactions, as described in preliminary simulations of the pre-polymerisation system, and as confirmed for the resultant MIP by HPLC data. Qualitative agreement is also observed between simulation and proton NMR data examining monomer self-association in the presence and absence of the template. On the basis of the data obtained, the role of a cross-linker appears to be more significant for this system than previously anticipated. ® The Royal Society of Chemistry
Template and target information: nonsteroidal anti-inflammatory drug, NSAID, naproxen, (S)-(+)-6-methoxy-α-methyl-2-naphthaleneacetic acid


  SMI logo drop earrings  Mug featuring the name Ian spelled out in the single letter amino acid code  Lab Chick script shirt






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner