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Reference type: Journal
Authors: Santos W, Lima PR, Tarley CRT, Kubota LT
Article Title: A catalytically active molecularly imprinted polymer that mimics peroxidase based on hemin: application to the determination of p-aminophenol.
Publication date: 2007
Journal: Analytical and Bioanalytical Chemistry
Volume: 389
Issue: (6)
Page numbers: 1919-1929.
DOI: 10.1007/s00216-007-1601-8

Abstract: Abstract: Despite the increasing number of applications of molecularly imprinted polymers (MIP) in analytical chemistry, the synthesis of polymers with hemin introduced as the catalytic center to mimic the active site of peroxidase remains as a challenge. In the current work, a new type of molecularly imprinted polymer (MIP) was synthesized with 4-aminophenol (4-APh) as the template and two monomers: hemin, which acts as the catalytic center, and methacrylic acid (MAA), which is used to build the active sites. This work shows that MIP successfully mimics peroxidase. For this purpose, a flow injection analysis system coupled to an amperometric detector was investigated through multivariate analysis. The determination of 4-APh was not affected by the equimolar presence of structurally similar phenol compounds, including catechol, 4-chloro-3-methylphenol, 2-aminophenol, guaiachol, chloroguaiachol and 2-cresol, thus highlighting the good performance of the imprinted polymer. Under the optimized experimental conditions, an analytical curve covering a wide linear response range from 0.8 up to 500 ?mol L?1 (r?>?0.999) was obtained, and the method gave satisfactory precisions (n?=?8), as evaluated via the relative standard deviation (RSD), of 4.1 and 3.2% for solutions of 4-APh of 50 and 500 ?mol L?1, respectively. Recoveries of 96111% from water samples (tap water and river water) spiked with 4-APh were achieved, thus illustrating the accuracy of the proposed system
Template and target information: 4-aminophenol, 4-APh
Author keywords: 4-Aminophenol, hemin, Molecularly imprinted polymers, Amperometric determination

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