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Reference type: Book Chapter
Authors: Danielsson B
Publication date: 2008
Chapter title: Artificial Receptors.
Page numbers: 97-122.
DOI: 10.1007/10_2007_088 Alternative URL: http://www.cntq.gob.ve/cdb/documentos/quimica/188.pdf

Book title: Biosensing for the 21st Century
Editors: Renneberg R, Lisdat F
Publisher: Springer
City: Berlin
Series title: Advances in Biochemical Engineering/Biotechnology
Series editors: Scheper T

Abstract: Herein I will provide a brief overview of artificial receptors with emphasis on molecularly imprinted polymers (MIPs) and their applications. Alternative techniques to produce artificial receptors such as in silico designed and modelled polymers as well as different receptors designed using libraries of more or less natural composition will also be mentioned. Examples of these include aptamers and bio-nanocomposites. The physical presentation of the receptors is important and may depend on the application. Block polymerization of MIPs and grinding to particles of suitable size used to be the preferred technique, but today beaded materials can be produced in sizes down to nanobeads and also nanofibers can be used to increase available surface area and thereby capacity. For sensor applications it may be attractive to include the artificial receptors in surface coatings or in membrane structures. Different composite designs can be used to provide additional desirable properties. MIPs and other artificial receptors are gaining rapidly increasing attention in very shifting application areas and an attempt to provide a systematic account for current applications has been made with examples from separation, solid-phase extraction, analysis, carbohydrate specific experiments, and MIPs-directed synthesis
Author keywords: Aptamers, combinatorial libraries, Ion channel sensors, MIP catalysis, MIPs, Molecularly imprinted polymers, Solid-phase extraction

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