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Reference type: Journal
Authors: Pan HH, Lee WC, Hung CY, Hwang CC
Article Title: Synthesis of molecularly imprinted polymer and its molecular recognition properties of N-acetylneuraminic acid.
Publication date: 2007
Journal: E-Journal of Chemistry
Volume: 4
Issue: (4)
Page numbers: 611-619.
DOI: 10.1155/2007/632904
Alternative URL: http://www.hindawi.com/journals/jchem/2007/632904/abs/

Abstract: A molecular imprinting technique was applied in this work to detect N-acetylneuraminic acid (Neu5Ac) and its analogue structure. Two molecularly imprinted polymers (MIP) were prepared using Neu5Ac as the template molecule, as well as methacrylic acid (MAA) or 4-vinylpyridine (4-Vpy) and ethyleneglycol dimethacrylate (EGDMA) as the functional monomer and cross-linker, respectively. Free radical polymerization was carried out at 4 C under UV radiation or thermal (60 C) polymerization. MIP thus obtained were ground into 11-25 μm and 25-44 μm. The binding results from Neu5Ac solution, mannose (Man) solution and N-acetyl-D-mannosamine (ManNAc) solution performed by Neu5Ac-MIP showed specific binding toward Neu5Ac rather than other analogue compounds on the host-guest system. The values of capacity for Neu5Ac-MIP were measured and experimental results were further used for simulation to obtain the binding isotherms. The principal advantage of this method is that Neu5Ac- MIP can recognize Neu5Ac and its analogue compounds
Template and target information: N-acetylneuraminic acid, Neu5Ac
Author keywords: Free radical polymerization, Host-guest system, molecularly imprinted polymer, N-acetylneuraminic acid, Specific binding

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