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Reference type: Journal
Authors: Hwang CC, Lee WC
Article Title: Chromatographic resolution of the enantiomers of phenylpropanolamine by using molecularly imprinted polymer as the stationary phase.
Publication date: 2001
Journal: Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
Volume: 765
Issue: (1)
Page numbers: 45-53.
DOI: 10.1016/S0378-4347(01)00397-8

Abstract: In this study molecular imprinting technology was employed to prepare a specific affinity sorbent for the resolution of phenylpropanolamine, a chiral drug. The molecularly imprinted polymer (MIP) was prepared by non-covalent molecular imprinting with either (-)- or (+)-phenylpropanolamine as the template. Methacrylic acid and ethylene glycol dimethacrylate were copolymerized in the presence of the template molecule. The bulk polymerization was carried out in chloroform with 2,2'- azobisisobutyronitrile as the initiator, at 4 degreesC and under UV radiation. The resulting MIP was ground into powders, which were slurry packed into analytical columns. After removal of template molecules, the MIP-packed columns were found to be effective for the resolution of ()-phenylpropanolamine racemates. The separation factor for the enantiomers ran-ed between 1.8 and 3.8 when the column was packed with MIP prepared with (+)-phenylpropanolamine as the template. A separation factor ranging from 2.1 to 3.6 could be achieved from the column packed with MIP, prepared with (-)- phenylpropanolamine as the template. Although the separation factor was higher with that previously obtained from reversed- phase column chromatography following derivatization with a chiral agent, elution peaks were broader due to the heterogeneity of binding sites on MIP particles and the possible non-specific interaction. (C) 2001 Elsevier Science B.V. All rights reserved


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