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Reference type: Journal
Authors: Yoshimatsu K, Ye L, Lindberg J, Chronakis IS
Article Title: Selective molecular adsorption using electrospun nanofiber affinity membranes.
Publication date: 2008
Journal: Biosensors and Bioelectronics
Volume: 23
Issue: (7)
Page numbers: 1208-1215.
DOI: 10.1016/j.bios.2007.12.002
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-4R9GGR7-2/2/c0e31436e17b5bb4aa693be5d5c54f4d

Abstract: Molecularly imprinted nanoparticles were encapsulated into polymer nanofibers with a simple electrospinning method. The composite nanofibers form non-woven mats that can be used as affinity membrane to greatly simplify solid phase extraction of drug residues in analytical samples. Upward 100% of propranolol-imprinted nanoparticles can be easily encapsulated into poly(ethylene terephthalate) nanofibers, ensuring the composite materials to have a high specific binding capacity. As confirmed by radioligand binding analysis, the specific binding sites in the composite materials remain easily accessible and are chiral-selective. Using the new composite nanofiber mats as solid phase extraction materials, trace amount of propranolol (1 ng mL-1) in tap water can be easily detected after a simple sample preparation. As validated in this study, there is no problem of template leakage from the composite nanofibers. Without the solid phase extraction, the existence of propranolol residues in water cannot be confirmed with even tandem HPLC-MS/MS analysis
Author keywords: molecular imprinting, electrospinning, Nanoparticle, nanofiber, affinity membrane, propranolol

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