Authors: Ikeda Y
, Siņeriz F
, Bultel L
, Grand E
, Kovensky J
, Papy-Garcia D
Synthesis of a trisulfated heparan sulfate disaccharide analog and its use as a template for preliminary molecular imprinting studies.
Publication date: 2008
Journal: Carbohydrate Research
Alternative URL: http://www.sciencedirect.com/science/article/B6TFF-4RFSCYP-3/2/739ded8a5c754f2b499bd4e06cb76fac
Abstract: A heparan sulfate disaccharide analog was synthesized by a multistep route. This synthesis was designed in such a way that one intermediate could be selectively deprotected to provide versatility during both synthesis and homologation of heparan sulfate related polysaccharides. Non-covalent imprinted polymers were prepared by using the synthesized disaccharide as a template and a primary amine functionalized acrylate as the key functional monomer suitable for specific sulfated sugar recognition. The binding of related sugars to the imprinted and non-imprinted polymers and the binding of template to the chemically modified polymers have been also investigated
Author keywords: Heparan sulfate, Disaccharide, imprinting, molecular recognition
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