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Reference type: Book Chapter
Authors: Gübitz G, Schmid MG
Publication date: 2003
Chapter title: Chiral Separation Principles.
Page numbers: 1-28.
DOI: 10.1385/1-59259-648-7:001

Book title: Chiral Separations
Editors: Gübitz G, Schmid MG
Series title: Methods in Molecular Biology
Volume number: 243

Abstract: The development of methods for chiral separation on an analytical as well as on a preparative scale has attracted great attention during the past two decades. Chromatographic methods such as gas chromatography (GC) (1), high-performance liquid chromatography (HPLC) (2–6), supercritical fluid chromatography (SFC) (7–9), and thin-layer chromatography (TLC) (10–13) have been developed using different chiral separation principles. More recently, capillary electrophoresis (CE) (14–21) and capillary electrochromatography (CEC) (22–25) have been shown to be powerful alternatives to chromatographic methods. Several separation principles successfully used in HPLC have been transferred to CE and CEC. For the separation of enantiomers on a preparative scale, LC has become increasingly attractive.


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