Authors: Boyd B
, Lundberg D
, Kronauer S
, Wihlborg A-K
Publication date: 2007
Tobacco-Specific Nitrosamines: Efficient Extraction of Toxic Compounds from Complex Matrices using Molecularly Imprinted Polymers
Supelco Technical Report
Alternative URL: http://www.sigmaaldrich.com/supelco/bulletin/t407117.pdf
Abstract: In an effort to develop a simple and highly sensitive assay for the extraction and analysis of TSNAs in urine, MIP Technologies AB has developed a molecularly imprinted polymer phase and validated an SPE method and analytical LC-MS-MS procedure specific for this application. In the validation study, effective limits of detection at low ppt level for all TSNAs (NNK, NAB, NNN, NAT) were achieved. In this report, the high performance of the molecularly imprinted polymer SPE material, the SupelMIP™ SPE-TSNAs, is further demonstrated.
Template and target information: tobacco-specific nitrosamines
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