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Reference type: Journal
Authors: Hu XG, Pan JL, Hu YL, Huo Y, Li GK
Article Title: Preparation and evaluation of solid-phase microextraction fiber based on molecularly imprinted polymers for trace analysis of tetracyclines in complicated samples.
Publication date: 2008
Journal: Journal of Chromatography A
Volume: 1188
Issue: (2)
Page numbers: 97-107.
DOI: 10.1016/j.chroma.2008.02.062
Alternative URL: http://www.sciencedirect.com/science/article/B6TG8-4S08YKB-1/2/720db28e4f6a2d7de3b443688414c42b

Abstract: Molecularly imprinted polymer (MIP) is widely used in many fields because of its characteristics of high selectivity, chemical stability and easy preparation. To enhance the selectivity and applicability of solid-phase microextraction (SPME), a novel MIP-coated SPME fiber was firstly prepared by multiple co-polymerization method with tetracycline as template. It could be coupled directly to high-performance liquid chromatography (HPLC) and used for trace analysis of tetracyclines (TCs) in complicated samples. The characteristics and application of the fibers were investigated. The electron microscope provided a crosslinked and porous surface, and the average thickness of the MIP coating was 19.5 μm. Compared with the non-imprinted polymer (NIP) coated fibers, the special selectivity to tetracycline and structure-similar oxytetracycline, doxycycline, chlortetracycline were discovered with the MIP-coated fibers. The adsorption and desorption of TCs with the MIP-coated fiber could be achieved quickly. A method for the fluorimetric determination of four TCs by the MIP-coated SPME coupled with HPLC was developed. The optimized extraction conditions such as extraction solvent, desorption solvent, and stirring speed were studied. Linear ranges for the four TCs were 5.00-200 μg/L and detection limits were within the range of 1.0-2.3 μg/L. The method was applied to simultaneous multi-residue analysis of four TCs in the spiked chicken feed, chicken muscle, and milk samples with the satisfactory recoveries
Author keywords: molecularly imprinted polymer, solid-phase microextraction, Tetracycline, high-performance liquid chromatography

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