MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Reimhult K, Yoshimatsu K, Risveden K, Chen S, Ye L, Krozer A
Article Title: Characterization of QCM sensor surfaces coated with molecularly imprinted nanoparticles.
Publication date: 2008
Journal: Biosensors and Bioelectronics
Volume: 23
Issue: (12)
Page numbers: 1908-1914.
DOI: 10.1016/j.bios.2008.02.011
Alternative URL: http://www.ntmdt.ru/data/media/files/publications/2008/reimhult_2008.pdf

Abstract: Molecularly imprinted polymers (MIPs) are gaining great interest as tailor-made recognition materials for the development of biomimetic sensors. Various approaches have been adopted to interface MIPs with different transducers, including the use of pre-made imprinted particles and the in situ preparation of thin polymer layers directly on transducer surfaces. In this work we functionalized quartz crystal microbalance (QCM) sensor crystals by coating the sensing surfaces with pre-made molecularly imprinted nanoparticles. The nanoparticles were immobilized on the QCM transducers by physical entrapment in a thin poly(ethylene terephthalate) (PET) layer that was spin-coated on the transducer surface. By controlling the deposition conditions, it was possible to gain a high nanoparticle loading in a stable PET layer, allowing the recognition sites in nanoparticles to be easily accessed by the test analytes. In this work, different sensor surfaces were studied by micro-profilometry and atomic force microscopy and the functionality was evaluated using quartz crystal microbalance with dissipation (QCM-D). The molecular recognition capability of the sensors were also confirmed using radioligand binding analysis by testing their response to the presence of the test compounds, (R)- and (S)-propranolol in aqueous buffer
Template and target information: propranolol
Author keywords: Molecularly imprinted polymers, quartz crystal microbalance, nanoparticles, sensors

  Periodic table Prof shirt  PhD Scientist peptide mug    Shirt featuring the template Propranolol

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner