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Reference type: Journal
Authors: Xu ZY, Wan JF, Liang S, Cao.X.J.
Article Title: Separation of ursodeoxycholic acid from its isomeric mixture using core-shell molecular imprinting polymer.
Publication date: 2008
Journal: Biochemical Engineering Journal
Volume: 41
Issue: (3)
Page numbers: 280-287.
DOI: 10.1016/j.bej.2008.05.019
Alternative URL: http://www.sciencedirect.com/science/article/B6V5N-4SP3SW0-1/2/32d4b4a7d450741b8dafaee9004767a0

Abstract: In order to separate ursodeoxycholic acid (UDCA) from its isomeric mixture, the molecular imprinting polymers (MIPs) were synthesized by using core-shell emulsion polymerization. In the porous imprinting polymer, ursodeoxycholic acid was used as imprinting molecule, acrylamide (AM) and α-methacrylic acid (MAA) were functional monomers, and CaCO3 was used for the porogen in the polymerization to obtain large pore. Characterization of the MIP structure with IR spectra demonstrated the expected MIPs. Through adsorption and selectivity assays, AM as the functional monomer showed better separation efficiency than MAA, and nonspecific and specific adsorption capacities of MIP with AM were 43.52 and 13.93mg/g, respectively. The separation factor of MIP with AM for UDCA was 2.20. Furthermore, MIP with AM could be applied to separate UDCA from the isomeric mixture by column chromatography successfully
Template and target information: ursodeoxycholic acid, UDCA
Author keywords: Ursodeoxycholic acid, Chenodeoxycholic acid, Core-shell molecular imprinting polymers

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