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Reference type: Journal
Authors: Figueiredo EC, Dias ACB, Arruda MAZ
Article Title: Molecular imprinting: A promising strategy in matrices elaboration for drug delivery systems.
Publication date: 2008
Journal: Brazilian Journal of Pharmaceutical Sciences
Volume: 44
Issue: (3)
Page numbers: 361-375.
DOI: 10.1590/S1516-93322008000300005
Alternative URL: http://www.scielo.br/scielo.php?script=sci_pdf&pid=S1516-93322008000300005&lng=en&nrm=iso&tlng=pt

Abstract: Biomolecular interactions (antigen-antibody, enzymesubstrate and drug-receptor) have been investigated due to their selective nature. Thus, since 1940, the search for synthetic materials presenting specific binding sites has been increasing. Nowadays, they are well established in different science areas such as pharmacy, analytical chemistry, biochemistry, among others, being the referred materials called molecularly imprinted polymers-MIP. Although the largest applications of MIP are found in the separations science field, few applications of these polymers have been reported as drug delivery systems-DDS. Such applications have been promising due to the feasibility of the MIP synthesis. However, the clinical use of the MIP as DDS is still not observed, probably due to its recent application, as well as extensive tests necessary for its approval as a new pharmaceutical form. In this way, this work aims to present the most recent progresses in the use of MIP as DDS, reinforcing the most significant aspects of this application (potentialities and limitations), as well as classifying and detailing such systems
Template and target information: Review - MIPs in drug delivery
Author keywords: Drug delivery system, Molecularly imprinted polymers


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