Authors: Andersson LI
Molecular imprinting for drug bioanalysis - A review on the application of imprinted polymers to solid-phase extraction and binding assay.
Publication date: 2000
Journal: Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
Abstract: Molecularly imprinted polymers have been applied as selective sorbents in several analytical techniques, including liquid chromatography, capillary electrophoresis and capillary electrochromatography, solid-phase extraction, and 'immunoassay'. An advantage of this type of sorbent is the possibility to synthesize polymers with selectivity pre-determined for a particular analyte. This review critically discusses the use of imprinted polymers for analysis of drugs and other compounds in biological samples, with emphasis on their use as highly selective solid-phase extraction sorbents for sample preconcentration and alternative binding entities in immunoassay type protocols. (C) 2000 Elsevier Science B.V. All rights reserved
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