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Reference type: Journal
Authors: Wang X, Wang LY, He XW, Zhang YK, Chen LX
Article Title: A molecularly imprinted polymer-coated nanocomposite of magnetic nanoparticles for estrone recognition.
Publication date: 2009
Journal: Talanta
Volume: 78
Issue: (2)
Page numbers: 327-332.
DOI: 10.1016/j.talanta.2008.11.024
Alternative URL: http://www.proteomics.dicp.ac.cn/publications/2009/9.pdf

Abstract: In this study, we synthesized Fe3O4 magnetic nanoparticles coated estrone-imprinted polymer with controlled size using a semi-covalent imprinting strategy. In this protocol, the estrone-silica monomer complex (EstSi) was synthesized by the reaction 3-(triethoxysilyl)propyl isocyanate with estrone, where the template was linked to the silica coating on the iron oxide core via a thermally reversible bond. The removal of the template by a simple thermal reaction produced specific estrone recognition sites on the surface of silica shell.The resulting estrone-imprinted polymer coating Fe3O4 magnetic hybrid nanoparticles exhibit a much higher specific recognition and saturation magnetization. The hybrid nanoparticles have been used for biochemical separation of estrone
Template and target information: estrone
Author keywords: Fe3O4 magnetic nanoparticles, molecularly imprinted polymer, Estrone, biochemical separation

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