MIPdatabase
Authors: Zhang QQ, Fu Q, Amut E, Fang Q, Zeng AG, Chang C
Article Title: Preparation and Evaluation of Propranolol-Imprinted Monolithic Stationary Phase by In Situ Technique and Application in Analysis of Propranolol in Biological Samples.
Publication date: 2009
Journal: Analytical Letters
Volume: 42
Issue: (3)
Page numbers: 536-554.
DOI: 10.1080/00032710802677084
Alternative URL: http://www.informaworld.com/10.1080/00032710802677084
Abstract: A propranolol molecule-imprinted monolithic stationary phase (MIMSP) was synthesized by in situ technique. The recognition mechanism of the polymers and the influences of some chromatographic conditions were examined by high-performance liquid chromatography (HPLC). The imprinted polymers showed much higher selectivity for β-blockers than the nonimprinted polymers (NIPs) did, which proves the successful preparation of propranolol-imprinted polymers by using an in situ technique. Then, this technique was used to prepare a molecularly imprinted polymer solid-phase extraction column to concentrate propranolol from biological samples. The results showed that the imprinted solid-phase extraction column could selectively enrich and purify propranolol from biological samples, such as plasma
Template and target information: β-blockers, propranolol
Author keywords: biological samples, molecularly imprinted polymer, monolithic stationary phase, propranolol
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