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Reference type: Journal
Authors: Zaidi SA, Han KM, Kim SS, Hwang DG, Cheong WJ
Article Title: Open tubular layer of S-ofloxacin imprinted polymer fabricated in silica capillary for chiral CEC separation.
Publication date: 2009
Journal: Journal of Separation Science
Volume: 32
Issue: (7)
Page numbers: 996-1001.
DOI: 10.1002/jssc.200800631

Abstract: An open tubular molecule imprinted polymer (OT-MIP) capillary column has been prepared for chiral separation of ofloxacin enantiomers in CEC. The S-ofloxacin imprinted OT column was fabricated by thermally initiated non-covalent polymerization procedure inside a pretreated and silanized fused silica capillary. The template molecule was incorporated with methacrylic acid (MAA), ethylene glycol dimethacrylate (EDMA) and 4-styrenesulfonic acid (4-SSA) and dissolved in a porogen mixture of ACN/2-propanol (9:1). The separation efficiency of the 4-SSA MIP column was found quite better than that of the MIP column without 4-SSA. It has been demonstrated that our OT-MIP column can separate ofloxacin enantiomers with excellent chiral separation efficiency after tuning the various chromatographic conditions. The optimized chromatographic eluent was 85:15, v/v%, ACN/60 mM sodium acetate at pH 7. The separation efficiency and selectivity of chiral separation of this study were far better than those obtained by previous methods for chiral separation of R- and S-ofloxacin
Template and target information: S-ofloxacin
Author keywords: CEC, chiral separation, Excellent separation efficiency and selectivity, Open tubular, S-Ofloxacin

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