Authors: Kempe M
Oxytocin receptor mimetics prepared by molecular imprinting.
Publication date: 2000
Journal: Letters In Peptide Science
Abstract: Oxytocin receptor mimetics were prepared by molecular imprinting using Z-oxytocin as the template. Comparative binding studies with reference polymers showed that the imprinted polymers recognized both Z-oxytocin and unprotected oxytocin selectively. The dissociation constants were 47 mu M and 102 mu M, respectively, and the density of binding sites was 12 mu mol/g. The synthetic oxytocin receptors were easily prepared, possessed high mechanical and chemical stability, and were reused without loss of selectivity and capacity after regeneration by extraction
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