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Reference type: Journal
Authors: Patel AK, Sharma PS, Prasad BB
Article Title: Electrochemical sensor for uric acid based on a molecularly imprinted polymer brush grafted to tetraethoxysilane derived sol-gel thin film graphite electrode.
Publication date: 2009
Journal: Materials Science and Engineering: C
Volume: 29
Issue: (5)
Page numbers: 1545-1553.
DOI: 10.1016/j.msec.2008.12.008
Alternative URL: http://www.sciencedirect.com/science/article/B6TXG-4V4VY49-2/2/06831fe645265898b5f0967afce09da5

Abstract: Determination of uric acid in human serum and urine is useful to provide treatment guidelines to hyperuricemic patients. An electrochemical sensor was developed for selective and quantitative recognition of uric acid by using a preanodised sol-gel coated graphite electrode with a molecularly imprinted polymer brush of poly(melamine-co-chloranil) grafted to its exterior surface. During a preconcentration step at (+2.0V versus saturated calomel electrode), the encapsulated analyte recapture involved hydrophobically induced hydrogen-bondings in outwardly exposed MIP cavities in aqueous environment (pH 7.0), instantly oxidised as dications, and then cathodically stripped off as corresponding lactam responding differential pulse, cathodic stripping voltammetric signal. The uric acid was selectively detected without any cross reactivity in the windows of 14.56-177.42g mL-1 (aqueous medium), 4.78-106.96g mL-1 (blood serum), and 7.81-148.42g mL-1 (urine) indicating detection limits in the range of 3.71-4.10g mL-1 (3σ, RSD=1.9%)
Template and target information: uric acid
Author keywords: Uric acid sensor, Molecularly imprinted polymer brush, sol-gel, Graphite electrode, differential pulse, Cathodic stripping voltammetry

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