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Reference type: Journal
Authors: Prasad BB, Tiwari K, Singh M, Sharma PS, Patel AK, Srivastava S
Article Title: Ultratrace Analysis of Dopamine Using a Combination of Imprinted Polymer-Brush-Coated SPME and Imprinted Polymer Sensor Techniques.
Publication date: 2009
Journal: Chromatographia
Volume: 69
Issue: (9)
Page numbers: 949-957.
DOI: 10.1365/s10337-009-1039-6

Abstract: Abstract: A combination approach in solid-phase microextraction, based on a molecularly imprinted polymer-brush coating on an optical fiber coupled with a complementary molecularly imprinted polymer sensor, has been adopted for isolation, preconcentration, and analysis of dopamine at ultratrace levels in highly dilute aqueous samples. This combination enabled enhanced (up to 8.5-fold) preconcentration of the analyte, which is appropriate for achieving a stringent detection limit in clinical diagnosis of several neurodegenerative diseases. The detection limit of dopamine in biological samples was 0.018 ng mL−1 with a relative standard deviation less than 2.1% and without any non-specific contributions
Template and target information: dopamine
Author keywords: solid-phase microextraction, Molecularly imprinted polymer brush, Molecularly imprinted polymer sensor, dopamine, aqueous samples

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