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Reference type: Journal
Authors: Schirmer C, Meisel H
Article Title: Chromatographic evaluation of polymers imprinted with analogs of chloramphenicol and application to selective solid-phase extraction.
Publication date: 2009
Journal: Analytical and Bioanalytical Chemistry
Volume: 394
Issue: (8)
Page numbers: 2249-2255.
DOI: 10.1007/s00216-009-2898-2

Abstract: Abstract To obtain a highly selective material for the antibiotic chloramphenicol, which has several harmful side effects in humans, different molecularly imprinted polymers (MIPs) were prepared. In order to avoid a major traditional drawback associated with MIPs of residual template bleeding, molecules that are structurally related to chloramphenicol were used as templates for polymer synthesis. Chromatographic evaluation indicated that the employed template imparted a significant influence on the recognition properties of the corresponding polymer. A strong retention of chloramphenicol under nonpolar elution conditions (k?=?68.03, IF?=?17.72) and under aqueous elution conditions (k?=?92.44, IF?=?1.35) was achieved. After chromatographic evaluation, the MIP was utilized as the recognition sorbent in a solid-phase extraction to determine chloramphenicol using either an organic or aqueous washing solvent. Recoveries of nearly 100% from the chloramphenicol standard solution and nearly 90% from honey samples spiked with chloramphenicol were attained. Furthermore, the applicability of the MIP for sample cleanup was demonstrated
Template and target information: Chloramphenicol, CAP
Author keywords: molecular imprinting, liquid chromatography, Solid-phase extraction, chloramphenicol, Honey

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