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Abstract: Hydroxy poly-chlorinated biphenyls (OH-PCBs) have been shown to inhibit mitochondrial oxidative phosphorylation, thyroid hormone sulfation, estrogen sulfotranferase and the sulfation and glucuronidation of 3-hydroxybenzo[a] pyrene, to affect thyroxine (T4) levels and to exhibit estrogenic or antiestrogenic activity. On the other hand, to achieve effective analysis of environmental organic as well as inorganic substances, adsorbents having specific molecular recognition ability are quite useful. The specific molecular recognition ability can be easily realized with a specially prepared polymer adsorbent, namely a molecularly imprinted polymer. In this study, we developed novel separation media having selective recognition ability for certain OH-PCBs by the fragment imprinted polymers. The results of high performance liquid chromatography (HPLC) showed that the selective structural recognition was worked for OH-PCBs on some imprinted polymers. (author abst.)
Template and target information: Hydroxy poly-chlorinated biphenyls, OH-PCBs, fragment imprint