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Reference type: Journal
Authors: Farber S, Green BS, Domb AJ
Article Title: Selective 17-β-estradiol molecular imprinting.
Publication date: 2009
Journal: Journal of Polymer Science Part A: Polymer Chemistry
Volume: 47
Issue: (20)
Page numbers: 5534-5542.
DOI: 10.1002/pola.23604

Abstract: An efficient novel method for the synthesis of a covalent molecularly imprinted polymer (MIP) highly specific to β-estradiol have been developed. MIP prepared by both covalent and non covalent techniques, demonstrated high selectivity toward β-estradiol. MIPs were synthesized by radical polymerization of 17-β-estradiol 4-vinyl-benzene carboxyl or sulfonyl esters used as covalent functional monomers, methacrylic acid as noncovalent functional monomer, ethylene glycol dimethacrylate as crosslinking agent, and acetonitrile as swelling and porogenic component. Almost 35% (w/w) of 17-β-estradiol was successfully removed from the polymer network by basic hydrolysis. The binding ability of MIP was 10.73 μg/mg MIP following removal of 17-β-estradiol in the 2 mg/mL β-estradiol solution. Selective rebinding of β-estradiol toward MIP was tested in the presence of competitive binders including estrone, 19-nortestosterone, epiandrosterone, and cholesterol. Estrone having closest similar chemical structure to β-estradiol exhibited only 0.6 mug/mg MIP competitive binding, being exposed to equivalent concentrations. Moreover, other competitive steroids demonstrated negligible affinity toward MIP indicating high selectivity of novel MIP system toward β-estradiol. 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 5534-5542, 2009
Template and target information: 17β-estradiol
Author keywords: 17β-estradiol, crosslinking, molecular imprinting, radical polymerization

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