MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Jiang M, Shi Y, Zhang RL, Shi CH, Peng Y, Huang Z, Lu B
Article Title: Selective molecularly imprinted stationary phases for Bisphenol A analysis prepared by modified precipitation polymerization.
Publication date: 2009
Journal: Journal of Separation Science
Volume: 32
Issue: (19)
Page numbers: 3265-3273A.
DOI: 10.1002/jssc.200900207

Abstract: Bisphenol A (BPA)-imprinted polymeric microspheres were synthesized by modified precipitation polymerization (MPP) method. Influences of cross-linker, monomer, porogen volume, and agitation on polymerization were investigated. Proper amount of cross-linker ethyleneglycol-dimethacrylate (EGDMA) was critical to achieve narrowly dispersed microspheres. For template BPA, monomer 4-vinylpyridine (4-VP) was better than MAA to get the best imprinted effects. The optimum template/monomer ratio was 1:6. Increasing porogen volume increased size dispersity and decreased binding characters. Agitation increased coagulation and resulted in irregular particles. Microspheres with the best binding characters were used as selective stationary phase of chromatographic column to detect BPA in milk, pig urine, and chicken meat. Under optimal chromatographic conditions, the calibration graph was linear with R2 = 0.9994 in the range of 3-50 mumol/L. The LOD and LOQ were 1 and 3 mumol/L, respectively. When large amounts (20 mL or 20 g) of samples were analyzed, the recoveries ranged from 70.2 to 87.3% with RSD less than 4.85% in all samples spiked with 0.05-0.2 mumol/L BPA. The intra-day and inter-day RSD were less than 1.83 and 3.96%, respectively. Microspheres prepared by MPP are successfully used in molecularly imprinted polymer (MIP)-based analytical column to detect trace BPA in different biologic samples with acceptable accuracy and repeatability
Template and target information: bisphenol A, BPA
Author keywords: Biologic samples, liquid chromatography, microspheres, Modified precipitation polymerization, Molecularly imprinted polymers, Selective stationary phase

  I love MIPs hat  multi MIPs logo mug    Mug featuring the template Bisphenol A

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner