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Reference type: Journal
Authors: Beltran A, Fontanals N, MarcÚ RM, Cormack PAG, Borrull F
Article Title: Molecularly imprinted solid-phase extraction of cephalexin from water-based matrices.
Publication date: 2009
Journal: Journal of Separation Science
Volume: 32
Issue: (19)
Page numbers: 3319-3326.
DOI: 10.1002/jssc.200900268

Abstract: In the present paper, we describe the synthesis of a cephalexin (CFX) molecularly imprinted polymer (MIP), the direct application of the MIP to SPE for the determination of CFX (which is a beta-lactam antibiotic) in human urine and the use of the MIP in a tandem SPE system to determine CFX in river water. The molecularly imprinted polymers (MIP) showed cross-selectivity for amoxicillin (AMX; also a beta-lactam antibiotic). This allowed both CFX and AMX to be quantified in acidified human urine, with recoveries of 78 and 60% for CFX and AMX, respectively, when the urine samples were spiked with CFX and AMX at 4 mg/L. These analyses were facile because the molecularly imprinted solid-phase extraction (MISPE) extracts were clear compared to the nonpurified samples. In order to increase the sample volume for river water analyses, a tandem SPE system incorporating a commercially available sorbent was implemented. With this set-up, CFX was determined with recoveries in excess of 50% when 200 mL of acidified river water samples spiked at 10 mug/L with CFX were percolated through the tandem system
Template and target information: cephalexin, CFX, amoxicillin, AMX
Author keywords: Amoxicillin, Cephalexin, molecularly imprinted polymer, River water samples, urine samples


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