MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Cutivet A, Schembri C, Kovensky J, Haupt K
Article Title: Molecularly Imprinted Microgels as Enzyme Inhibitors.
Publication date: 2009
Journal: Journal of the American Chemical Society
Volume: 131
Issue: (41)
Page numbers: 14699-14702.
DOI: 10.1021/ja901600e

Abstract: We demonstrate, on the example of trypsin, the use of water-soluble molecularly imprinted polymer microgels as specific enzyme inhibitors. Using a strong anchoring monomer, methacryloylaminobenzamidine, the growing polymer chains are confined to close proximity of the substrate recognition site of our model enzyme. The microgels bind selectively trypsin over other proteins of similar size and molecular weight, and show competitive inhibition of trypsin with an inhibition constant Ki of 79 nM, making them more potent inhibitors than the low molecular-weight competitive inhibitor benzamidine by almost 3 orders of magnitude. We believe that these tailor-made materials with biological activity have potential for future drug development that extends beyond enzyme inhibition
Template and target information: trypsin, protein, enzymes

  Shirt featuring the name Arnaud spelled out in symbols of the chemical elements  Mug featuring the name Karsten spelled out in the single letter amino acid code  Lab Chick script shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner