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Abstract: A novel electrochemical sol-gel imprinted sensor was developed via molecular imprinting technique, sol-gel technology and self-assembled membrane method, and thin film of molecularly imprinted sol-gel polymers with the specific binding sites for clindamycin was cast on MWNTs modified gold electrode by electropolymerization. The electrochemical performance and morphology of imprinted sol-gel film were charecterized by cyclic voltammetry(CV), differential pulse voltammetry(DPV), amperometric I-t curve and scanning electron microscope(SEM). The results show that the sensor has good selectivity and sensitivity, and the response to clindamycin on the MWNTs modified sol-gel imprinted sensor increases clearly. The linear range is over the range from 5.0 x 10(-7)-8.0 x 10(-5) mol/L, and the limit of detection is 2.44 x 10(-8) mol/L. The sensor has been successfully employed to detect clindamycin in human urine
Template and target information: clindamycin
Author keywords: Molecularly imprinted sol-gel, Multi-wall carbon nanotubes, Electrochemical sensor, electropolymerization, Clindamycin