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Reference type: Journal
Authors: Caldorera-Moore M, Peppas NA
Article Title: Micro- and nanotechnologies for intelligent and responsive biomaterial-based medical systems.
Publication date: 2009
Journal: Advanced Drug Delivery Reviews
Volume: 61
Issue: (15)
Page numbers: 1391-1401.
DOI: 10.1016/j.addr.2009.09.002
Alternative URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788786/

Abstract: Advances in medical treatments of a wide variety of pathophysiological conditions require the development of better therapeutic agents, as well as a combination of the required therapeutic agents with device-integrated biomaterials that can serve as sensors and carriers. Combination of micro- and nano-fabricated systems with intelligent biomaterials that have the ability to sense and respond is a promising avenue for the development of better diagnostic and therapeutic medical systems. Micro- and nano-electromechanical systems (MEMs and NEMs) are now becoming a family of potentially powerful new technologies for drug delivery, diagnostic tools, and tissue engineering. Improvements in micro- and nano-fabrication technologies have enhanced the ability to create better performing therapeutic systems for numerous pathophysiological applications. More importantly, MEMS- and NEMS-based tissue regeneration scaffolds, biosensors, and drug delivery devices provide new opportunities to mimic the natural intelligence and response of biological systems
Template and target information: Review - medical biomaterials
Author keywords: Responsive hydrogels, Intelligent therapeutics, Micro- and nano-electromechanical systems, Biosensors, controlled drug delivery, tissue engineering

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