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Reference type: Journal
Authors: da Silva MS, Vo ER, Temtem M, Mafra L, Caldeira J, Aguiar-Ricardo A, Casimiro T
Article Title: Clean synthesis of molecular recognition polymeric materials with chiral sensing capability using supercritical fluid technology. Application as HPLC stationary phases.
Publication date: 2010
Journal: Biosensors and Bioelectronics
Volume: 25
Issue: (7)
Page numbers: 1742-1747.
DOI: 10.1016/j.bios.2009.12.023
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-4Y1MRCF-2/2/710070d9f6d3d3092e4ebf442021cc95

Abstract: Molecularly imprinted polymers (MIPs) of poly(ethylene glycol dimethacrylate) and poly(N-isopropylacrylamide-co-ethylene glycol dimethacrylate) were synthesized for the first time in supercritical carbon dioxide (scCO2), using Boc-l-tryptophan as template. Supercritical fluid technology provides a clean and one-step synthetic route for the preparation of affinity polymeric materials with sensing capability for specific molecules. The polymeric materials were tested as stationary HPLC phases for the enantiomeric separation of l- and d-tryptophan. HPLC results prove that the synthesized MIPs are able to recognize the template molecule towards its enantiomer which opens up potential applications in chromatographic chiral separation
Template and target information: Boc-l-tryptophan
Author keywords: Supercritical fluid technology, molecular imprinting, MIP, Tryptophan, enantiomeric separation, HPLC

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