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Reference type: Journal
Authors: Figueiredo EC, Sanvido GB, Arruda MAZ, Eberlin MN
Article Title: Molecularly imprinted polymers as analyte sequesters and selective surfaces for easy ambient sonic-spray ionization.
Publication date: 2010
Journal: Analyst
Volume: 135
Issue: (4)
Page numbers: 726-730.
DOI: 10.1039/b923289c
Alternative URL: http://www.rsc.org/Publishing/Journals/AN/article.asp?doi=b923289c

Abstract: The use of a molecularly imprinted polymer (MIP) as a selective surface for ambient mass spectrometry is demonstrated. The MIP is used to sequester target analytes from urine and easy ambient sonic-spray ionization mass spectrometry (EASI-MS) is shown to be able to efficiently desorb the analytes from the MIP surface and then transfer them in protonated forms to the gas phase for MS analysis. A set of five phenothiazines (chlorpromazine, perphenazine, triflupromazine, thioridazine and prochlorperazine) were chosen from a proof-of-principle class of drug samples. A chlorpromazine-imprinted methacrylic polymer was synthesized and used to prepare a MIP probe. The MIP-EASI-MS technique using acidified methanol as solvent has been shown to allow quantification of all five drugs in urine with LOQ of ca. 1 mol L-1
Template and target information: chlorpromazine, perphenazine, triflupromazine, thioridazine, prochlorperazine, phenothiazines


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