MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Arenas LF, Ebarvia BS, Sevilla FB
Article Title: Enantioselective piezoelectric quartz crystal sensor for d-methamphetamine based on a molecularly imprinted polymer.
Publication date: 2010
Journal: Analytical and Bioanalytical Chemistry
Volume: 397
Issue: (7)
Page numbers: 3155-3158.
DOI: 10.1007/s00216-010-3865-7

Abstract: Abstract: A piezoelectric quartz crystal (PQC) sensor based on a molecularly imprinted polymer (MIP) has been developed for enantioselective and quantitative analysis of d-(+)-methamphetamine (d(+)-MA). The sensor was produced by bulk polymerization and the resulting MIP was then coated on the gold electrode of an AT-cut quartz crystal. Conditions such as volume of polymer coating, curing time, type of PQC, baseline solvent, pH, and buffer type were found to affect the sensor response and were therefore optimized. The PQC-MIP gave a stable response to different concentrations of d(+)-MA standard solutions (response time = 10 to 100 s) with good repeatability (RSD = 0.03 to 3.09%; n = 3), good reproducibility (RSD = 3.55%; n = 5), and good reversibility (RSD = 0.36%; n = 3). The linear range of the sensor covered five orders of magnitude of analyte concentration, ranging from 10-5 to 10-1 μg mL-1, and the limit of detection was calculated as 11.9 pg d(+)-MA mL-1 . The sensor had a highly enantioselective response to d(+)-MA compared with its response to l(-)-MA, racemic MA, and phentermine. The developed sensor was validated by applying it to human urine samples from drug-free individuals spiked with standard d(+)-MA and from a confirmed MA user. Use of the standard addition method (SAM) and samples spiked with d(+)-MA at levels ranging from 1 x 10-3 to 1 x 10-2 μg mL-1 showed recovery was good (95.3 to 110.9%)
Template and target information: d-(+)-methamphetamine, d(+)-MA, methamphetamine
Author keywords: piezoelectric quartz crystal, molecularly imprinted polymer, Methamphetamine, Enantioselective sensor


  I love MIPs shirt  multi MIPs logo mug  British periodic table patriotic tote bag

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner