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Reference type: Journal
Authors: Lämmerhofer M, Gargano A
Article Title: Monoliths with chiral surface functionalization for enantioselective capillary electrochromatography.
Publication date: 2010
Journal: Journal of Pharmaceutical and Biomedical Analysis
Volume: 53
Issue: (5)
Page numbers: 1091-1123.
DOI: 10.1016/j.jpba.2010.05.026
Alternative URL: http://www.sciencedirect.com/science/article/B6TGX-507CRP8-2/2/46a80e4c6d1fd44c8020c87700a5a3da

Abstract: The state-of-the-art in CEC enantiomer separations with monolithic capillary columns is comprehensively reviewed. The various types of monolithic columns comprising in situ organic polymer monoliths, molecularly imprinted polymer (MIP) monoliths, silica monoliths and monoliths made from particles are discussed with a focus on materials' synthesis, chemistry and properties as well as column aspects. Monolithic MIP-type porous layer open-tubular (PLOT) columns are treated herein as well. From this survey of the literature, the authors come to the conclusion that monolithic silica capillaries appear to become the preferred column type for CEC enantiomer separations of low-molecular drugs and other chiral pharmaceuticals or chemicals
Template and target information: Review - enantiomer separation by CEC
Author keywords: capillary electrochromatography, enantiomer separation, Organic polymer and silica monolith, molecularly imprinted polymer, chiral stationary phase


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