MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Conference Proceeding
Authors: Lanza F, Ruther M, Hall AJ, Dauwe C, Sellergren B
Publication date: 2002
Article title: Studies on the process of formation, nature and stability of binding sites in molecularly imprinted polymers.
Page numbers: 93-103
DOI: 10.1557/PROC-723-M5.6 Alternative URL: https://www.researchgate.net/publication/235210387_Studies_on_the_Process_of_Formation_Nature_and_Stability_of_Binding_Sites_in_Molecularly_Imprinted_Polymers

Editors: Shea KJ, Yan M, Roberts MJ, Cremer PS, Crooks RM, Sailor MJ
Publisher: Materials Research Society
Volume number: 723
Conference information: Molecularly Imprinted Materials-Sensors And Other Devices

Abstract: In Molecular Imprinting the nature of the templated binding sites and the mechanism of their formation are still poorly understood. For this reason our groups are carrying out fundamental studies concerning known imprinting protocols, with the primary aim of shedding light on the role of the template in the different steps of the polymerisation, from the formation of primary chains to the build-up of the porous structure. In this paper we report our initial results concerning copolymers of methacrylic acid (MAA) and ethyleneglycol dimethacrylate (EDMA) and their formation in presence or absence of the templates 9-ethyladenine, ametryn or terbutylazine. Monitoring the monomer disappearance by H-1-NMR showed that the presence of templates such as 9-ethyladenine significantly retarded the polymerisation but otherwise had minor influence on the relative reactivity of the monomers. The latter appeared in most cases to be stoichiometricatly incorporated into the polymer. The signals arising from the template experienced little or no shift in the early stage of the polymerisation, although pronounced broadening was observed. By delaying the addition of the template, it was observed that binding sites with high selectivity could be induced more than one hour after the gel point of the system had been passed. Finally, the results of post-polymerisation curing on the dry and swollen state porosities and the recognition properties of terbutylazine imprinted polymers are reported. This treatment when performed at temperatures between 100-120degreesC, slightly enhanced the selectivity of the polymers, whereas at higher temperatures the polymers lost their molecular recognition properties. Swollen state porosity derived from inverse size exclusion chromatography (ISEC) revealed an interesting sharpening of the pore size distribution for the imprinted compared to the non-imprinted polymers

  Bag featuring the name Francesca spelled out in symbols of the chemical elements  Mug featuring the name Christian spelled out in the single letter amino acid code  We need to talk about Kelvin shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner