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Reference type: Book Chapter
Authors: Miyata T
Publication date: 2010
Chapter title: Biomolecule-Responsive Hydrogels.
Page numbers: 65-86.
DOI: 10.1007/978-1-4419-5919-5_4

Book title: Biomedical Applications of Hydrogels Handbook
Editors: Park K, Okano T
Publisher: Springer
City: New York
ISBN: 978-1-4419-5919-5

Abstract: Biomolecule-responsive hydrogels that exhibit volume changes in response to target biomolecules have become increasingly important because of their potential applications as smart biomaterials. Researchers are developing novel biomedical systems using glucose, proteins and other biomolecule-responsive hydrogels as biosensing systems for applications such as drug delivery and cell culture systems. In the synthesis of biomolecule-responsive hydrogels, both biomolecular recognition and responsive functions that perceive a target biomolecule and induce structural changes must be introduced into the hydrogels network. Many biomolecule-responsive hydrogels are prepared by combining structural designs of hydrogels networks with molecular recognition events of biomolecules, such as enzymes, lectins and antibodies. Most important is the need to synthesize and develop more biomolecule-responsive hydrogels in tandem with their biomedical applications so that the field continues to evolve

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