MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Tehrani MS, Vardini MT, Azar PA, Husain SW
Article Title: Molecularly imprinted polymer based PVC-membrane-coated graphite electrode for the determination of metoprolol.
Publication date: 2010
Journal: Journal of the Iranian Chemical Society
Volume: 7
Issue: (3)
Page numbers: 759-769.
Alternative URL: http://www.ics-ir.org/jics/archive/v7/3/article/pdf/JICS-7-3-Article-25.pdf

Abstract: A PVC-based membrane containing metoprolol molecularly imprinted polymer (MIP) coated directly on graphite electrode for the determination of metoprolol in real samples is reported. This potentiometric sensor was designed by dispersing the MIP particles in dioctylphthalate plasticizer as solvent mediator and then embedded in polyvinyl chloride matrix. The electrode exhibited a near-Nernstian slope of 55.4 1 mV decade-1 for metoprolol over a wide concentration range between 2.0 x 10-7-8.0 x 10-3 M and a detection limit of 1.3 + 10-7 M. With a response time of about 14 s it could be used for at least 6 months without any divergence in potential. The proposed electrode can be used in the pH range of 3.5-10.5 and can reveal good selectivities for metoprolol over a wide variety of ions. Finally, the designed sensor was successfully applied as an indicator electrode to determine the concentration of metoprolol in tablets, human urine and plasma. The results were compared favorably with those obtained by HPLC method and showed satisfactory agreements with them
Template and target information: metoprolol
Author keywords: Coated graphite, Ion-selective electrode, Metoprolol, molecularly imprinted polymer, PVC-membrane

  Eat, sleep, imprint, repeat greetings card  SMI logo mug  Woman of proper-tea mug in green

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner