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Reference type: Journal
Authors: von Hauff E, Fuchs K, Hellmann DC, Parisi J, Weiler R, Burkhardt C, Kraushaar U, Guenther E
Article Title: Biocompatible molecularly imprinted polymers for the voltage regulated uptake and release of l-glutamate in neutral pH solutions.
Publication date: 2010
Journal: Biosensors and Bioelectronics
Volume: 26
Issue: (2)
Page numbers: 596-601.
DOI: 10.1016/j.bios.2010.07.022
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-50J9GVF-2/2/32f8c4cd2605b58a3b4758da916964cc

Abstract: A biocompatible device for the voltage dependent uptake and release of the neural transmitter l-glutamate in neutral pH solutions is demonstrated. The device consists of a gold electrode coated with molecularly imprinted, overoxidised polypyrrole (oPPy). It is shown here that oPPy can behave as an anion exchanger in neutral pH. The voltage dependent uptake and release of glutamate from the oPPy as well as the enantioselectivity of the polymer layer for l-glutamate over d-glutamate are investigated in neutral pH solutions using electrochemical quartz crystal microbalance techniques. The biocompatibility of the oPPy layer is demonstrated using retinae from young rats. The retinae were isolated and the dissociated cells were kept in culture for up to 1-week. The cells were exposed to the oPPy layers for 3 days, and there is no significant difference in the survival rate between the cells cultured on the oPPy layers and the control samples. Additionally the cell-polymer interface from cells grown directly on the oPPy layers is investigated using electron microscopy
Template and target information: l-glutamate
Author keywords: Molecularly imprinted polymers, l-Glutmate, polypyrrole


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