MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Pietrzyk A, Suriyanarayanan S, Kutner W, Maligaspe E, Zandler ME, D'Souza F
Article Title: Molecularly imprinted poly[bis(2,2'-bithienyl)methane] film with built-in molecular recognition sites for a piezoelectric microgravimetry chemosensor for selective determination of dopamine.
Publication date: 2010
Journal: Bioelectrochemistry
Volume: 80
Issue: (1)
Page numbers: 62-72.
DOI: 10.1016/j.bioelechem.2010.03.004
Alternative URL: http://www.sciencedirect.com/science/article/B6W72-4YPPR41-2/2/a6cf53c17f965380213b0f089c720efc

Abstract: A piezoelectric microgravimetry (PM) chemosensor, featuring a film of molecularly imprinted polymer (MIP) of poly[bis(2,2'-bithienyl)methane] bearing either a 3,4-dihydroxyphenyl or benzo-18-crown-6 substituent, for selective determination of dopamine was devised and tested. A Pt/quartz resonator and a dopamine-templated MIP film, deposited by electropolymerization onto an underlayer of poly(bithiophene), served as the transducer and recognition element of the chemosensor, respectively. The UV-vis spectroscopic and XPS as well as electrochemical measurements verified completeness of the dopamine template extraction with a strong base solution. The extraction-generated molecular cavities featured recognition sites that served selective dopamine analyte binding. The SECM imaging substantiated the permeability characteristics of the template-free MIP film. The dopamine analyte was determined under FIA conditions with the PM detection. The lower limit of detection was 10 nM dopamine at favorable conditions involving the 35 μL/min carrier solution flow rate and the injected sample volume of 1 mL. The sensitivity of the chemosensor increased almost fivefold when the poly(bithiophene) film coated Pt/quartz electrode was used instead of the bare Pt/quartz electrode as the substrate for deposition of the MIP film. The chemosensor successfully discriminated dopamine from structural and functional analogues, such as 2-phenylethylamine, histamine, and ascorbic acid. The optimum mean thickness of the MIP film was ~ 220 nm
Template and target information: dopamine
Author keywords: Molecularly imprinted polymers, Dopamine piezoelectric microgravimetry chemosensor, Bis(2,2'-bithienyl)methane Electropolymerization, Barrier layer, Poly(bithiophene)

  SMI logo travel mug  Mug featuring the name Francis spelled out in the single letter amino acid code  Lab Chick script shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner