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Reference type: Journal
Authors: Zhang ZH, Liu L, Li H, Yao SZ
Article Title: Preparation and Evaluation of Uniform-Sized Sol-Gel Theophylline Imprinted Microspheres as Solid Phase Extraction Sorbent.
Publication date: 2010
Journal: Analytical Letters
Volume: 43
Issue: (15)
Page numbers: 2318-2330.
DOI: 10.1080/00032711003717364
Alternative URL: http://www.informaworld.com/10.1080/00032711003717364

Abstract: A highly selective imprinted amino-functionalized silica gel microsphere was prepared by a simple molecular imprinting technique with a sol-gel process. Theophylline was used as template; 3-aminopropyltrimethoxysilane (APTMS) as functional monomer and tetraethylorthosilicate (TEOS) as reticulating agent. These theophylline imprinted silica microspheres were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron micrographs (SEM), thermogravimetric analysis (TGA), and high performance liquid chromatography (HPLC) in detail. The results showed that monodispersive APTMS-silica imprinted microspheres with size of 250-nm were synthesized successfully. Two kind of binding sites exist between the sol-gel imprinted microspheres and theophylline with KD and Qmax for the higher affinity binding parameters was 1.89 μg/mL and 7.47 μg/mg dry polymers, and for the lower affinity binding sites were found to be 0.18 μg/mL and 3.47 μg/mg dry polymers, respectively. Packed in column, the imprinted microspheres were employed to extract theophylline from green tea successfully
Template and target information: theophylline


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