MIPs logo MIPdatabase      Special issue call for papers   
Custom Search
Reference type: Journal
Authors: Alvarez-Lorenzo C, Yañez F, Concheiro A
Article Title: Ocular drug delivery from molecularly-imprinted contact lenses.
Publication date: 2010
Journal: Journal of Drug Delivery Science and Technology
Volume: 20
Issue: (4)
Page numbers: 237-248.
Alternative URL: http://www.editionsdesante.fr/category.php?id_category=16

Abstract: Soft contact lenses (SCLs) are particularly attractive as drug delivery devices capable of overcoming certain limitations of conventional ophthalmic formulations. Although the main use of commercially-available SCLs is for correcting ametropia problems, they may also uptake certain drugs and release them into the postlens lachrymal fluid, minimizing the clearance and the sorption through the conjunctiva. Novel approaches to enhance the capability of SCLs to load drugs and control release may make these optical devices behave as advanced drug delivery systems, fulfilling the requirements of both chronic and acute ocular diseases. Among those approaches, the application of the molecular imprinting technology during SCL manufacture enables the creation in the lens structure of imprinted pockets that memorize the spatial features and bonding preferences of the drug and provide the lens with a high affinity for a given drug. Imprinted SCLs could prolong the permanence of the drug in the precorneal area and provide sustained drug levels, increasing ocular bioavailability and avoiding systemic side-effects. In this review, the potential and the advantages/drawbacks of drug-imprinted SCLs are critically analyzed and examples of the application of the molecular imprinting technology to β-adrenergic antagonist, antimicrobials, antihistamines and ocular comfort ingredients are shown
Template and target information: Review - MIPs in contact lenses
Author keywords: Drug-eluting device, Hyaluronic acid, Ketotifen, molecular imprinting technology, norfloxacin, Soft contact lens, Sustained delivery, timolol

  Periodic table Crab Cakes - the chemical formula for a fishy snack shirt  Mug featuring the name Carmen spelled out in the single letter amino acid code  Meerkat somebody mention coffee mug


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner