MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Pernites RB, Ponnapati RR, Advincula RC
Article Title: Surface Plasmon Resonance (SPR) Detection of Theophylline via Electropolymerized Molecularly Imprinted Polythiophenes.
Publication date: 2010
Journal: Macromolecules
Volume: 43
Issue: (23)
Page numbers: 9724-9735.
DOI: 10.1021/ma101868y
Alternative URL: http://mynsm.uh.edu/sandbox/groups/advincularesearchgroup/wiki/a93f3/attachments/6df24/SPR-MIP.pdf

Abstract: A facile approach to tailor-made, highly selective, and robust ultrathin sensor film for theophylline detection was demonstrated by an electropolymerized molecularly imprinted polymer (E-MIP) film of a terthiophene derivative. The method involved direct electropolymerization of the H-bond complexing terthiophene monomer. A key enabling step in sensor fabrication is the use of an electrochemically mediated washing step of the template. The formation of the E-MIP film was monitored by in situ electrochemical surface plasmon resonance (EC-SPR) spectroscopy, allowing real-time observation of the simultaneous changes in electrochemical and optical properties of the film. Surface characterization techniques for the electropolymerized films include atomic force microscopy (AFM), ellipsometry, static contact angle, X-ray photoelectron spectroscopy (XPS), and quartz crystal microbalance (QCM). A linear calibration curve (R = 0.994) of the E-MIP/SPR sensor for theophylline detection was obtained with a 10-50 μM-1 range and a limit of detection (LOD) of 3.36 μM-1. The fabricated E-MIP sensor film showed a homogeneous surface coverage, high sensitivity, long-term stability, and strong selectivity toward the imprinted template molecule. This indicated the formation of precise and stable cavities that retained the exact memory of the size, shape, and orientation of the functional groups during the templating electropolymerization steps
Template and target information: theophylline

  Eat, sleep, imprint, repeat mug  SMI logo mug    Mug featuring the template Theophylline

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner