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Abstract: Four types of molecularly imprinted polymers (MIP) were synthesized using atenolol, metoprolol, nimodipine and ketoconazole as template molecules through a molecular imprinting technique. The adsorption properties and selectivity ability of MIP were studied with UV equilibrium adsorption procedures. The results suggested that atenolol and metoprolol imprinted polymers exhibited a good rebinding ability for the template, whereas nimodipine and ketoconazole polymers showed almost no rebinding adsorption. Scatchard analysis indicated that at least two different classes of recognition sites were formed during the course of self-assembly between monomers and templates through hydrogen bond or ionic bond. The crossed binding experiment for different substrates showed that atenolol and metoprolol imprinted polymers possessed excellent selectivity toward the template compared to the analogs. The values of the separation factor a of atenolol and metoprolol imprinted polymers reached 1.75 and 1.62, and whereas the a values of corresponding blank polymers were only 1.07 and 0.97. (Analytical Abstracts 2005)
Template and target information: atenolol, metoprolol, nimodipine, ketoconazole
Author keywords: molecularly imprinted polymer, template, Scatchard analysis, atenolol, Metoprolol