MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Liu C, Muhammad T, Hudaberdi N, Piletska EV, Zeng HH
Article Title: Synthesis of Lidocaine Molecularly Imprinted Polymers and Application on Solid Phase Extraction.
Publication date: 2010
Journal: Chinese Journal of Analytical Chemistry
Volume: 38
Issue: (11)
Page numbers: 1652-1656.
DOI: 10.3724/SP.J.1096.2010.01652
Alternative URL: http://en.cnki.com.cn/Article_en/CJFDTotal-FXHX201011025.htm

Abstract: Itaconic acid was selected as the best template for lidocaine molecularly imprinted polymer (MIP) through computational investigation and template-monomer interaction experiment. The MIP was prepared using ethylene glycol dimethacrylate as crosslinker and dimethylformamide as porogen. High retention factor and selectivity were achieved by HPLC evaluation of MIPs as column sorbent. After optimization of SPE profile, it was found that the best imprinting effect was obtained with loading in acetonitrile, washing with methanol-acetonitrile (5:95, V/V), eluting with hydrochloric acid-methanol (5:95, V/V). MIP and nonimprinted polymer (NIP) showed surprisingly high binding capacity in acetonitrile in breakthrough curve, and their capacities are 1.62 and 0.92 mg of drug to 100 mg of adsorbent respectively. Concentration of lidocaine in spiked serum was determined by visible spectrophotometric measurement of the SPE eluent, with the average recovery of 84.6%
Template and target information: lidocaine
Author keywords: molecularly imprinted polymer, solid phase extraction, Lidocaine, Visible spectrophotometry

  I love MIPs shirt  Mug featuring the name Elena spelled out in the single letter amino acid code  British periodic table patriotic tote bag

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner