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Abstract: Abstract: A new molecularly imprinted polymer (MIP) for levofloxacin was prepared by the combined use of methacrylic acid and protoporphyrin as functional monomers. The adsorption properties of resultant imprinted polymers were evaluated by equilibrium rebinding experiments. The highest binding capacity of levofloxacin achieved from the optimized imprinted polymer in acetonitrile was 246.26 μmol/g with an imprinting factor of 2.05. A Fluorescence quenching effect was observed when a protoporphyrin-based imprinted polymer was incubated in the solutions of levofloxacin. The results indicated that the protoporphyrin-based MIPs were able to create higher binding cavities for template compared with MIPs using only methacrylic acid as a functional monomer. It should be expected that the cooperative use of the protoporphyrin with supplemental different functional monomers may be an alternative to obtain MIP with the improvement of the selectivity. Copyright © 2010 John Wiley & Sons, Ltd
Template and target information: levofloxacin
Author keywords: Levofloxacin, molecularly imprinted polymer, protoporphyrin, affinity, co-Monomer